What can Modafinil do to ease anxiety?

Modafinil can reduce extreme sleepiness caused by narcolepsy or other sleep disorders such as obstructive sleep disorder (obstructive sleeping apnea) and periods of stopped breathing while you sleep. Modafinil can also be used to keep you awake at work if your work schedule makes it difficult for you to have a regular sleeping pattern (shift work sleep disorder). Modafinil does not take the place of getting enough sleep. It should not treat tiredness or hold off rest in people who do not have a sleep disorder. It is not known how Modafinil works to keep you awake. It is thought to work by affecting certain substances in the brain that control the sleep/wake cycle.

Modafinil  Australia Reddit has effects on catecholamines and serotonin. It is also known as Provigil in the United States. These effects could be secondary to catecholamines and may have a selectivity for subcortical rather than cortical sites. Modafinil promotes wakefulness. The FDA has approved Modafinil to treat excessive sleepiness in narcolepsy, sleep disorders resulting from shift work and sleep disorder obstructive/hypopnea. In addition to its application for sleep disorders, it has been used off-label as a psychostimulant to treat cognitive dysfunction in some psychiatric conditions, such as schizophrenia, attention-deficit/hyperactivity disorder, and a general cognitive enhancer in normals.

Preclinical data suggest that Modafinil may improve working memory performance in a dose and delay-dependent fashion. Modafinil may also enhance the processing of context cues. Sustained dosing regimens can augment these effects. Studies in humans have shown Modafinil improves recognition memory, working memory, and other cognitive tasks in healthy subjects, whether or not they are sleeping deprivation. There is evidence Modafinil may improve attention and response inhibition among ADHD children and adolescents in psychiatric populations. Studies have also shown that Modafinil may improve cognitive functions in adults with ADHD, major depression, and schizophrenia.

Modafinil seems to be associated with anxiety in humans and animals. However, the evidence is mixed and may be dose-dependent. Modafinil showed no similar effects to amphetamine in mice. The increased anxiety measures in mice due to increased latency in exploring a white compartment increased open field thigmotaxis and decreased time spent in open arms in an elevated plus-maze. Modafinil did not cause anxiety in monkeys after being administered at the increased nocturnal activity. This was confirmed by Hermant, Rambert and Duteil (1991). Wong et al. 1999 reported that Modafinil causes pressure to increase at doses between 200 and 800 mg. A second study on mood and cognitive function of healthy young adults revealed that modafinil 100 mg was associated with more anxiety symptoms than placebo. However, modafinil 200 mg did not cause these effects. Modafinil 400mg daily for three days was reported to make healthy adults feel calmer than those given a placebo. Similar results were found in placebo-controlled studies that modafinil administration was associated with anxiety in patients with myotonic disorder, patients suffering from obstructive sleeping apnea, and multiple sclerosis. The literature indicates that Modafinil can cause stress in both healthy and clinical populations. Its role in augmenting the learning process of extinction (and its potential role as enhanced anxiety in this process) is still being studied.

Modafinil can reduce extreme sleepiness caused by narcolepsy or other sleep disorders such as obstructive sleep disorder (obstructive sleeping apnea) and periods of stopped breathing while you sleep. Modafinil can also be used to keep you awake at work if your work schedule makes it difficult for you to have a regular sleeping pattern (shift work sleep disorder). Modafinil does not take the place of getting enough sleep. It should not treat tiredness or hold off rest in people who do not have a sleep disorder. It is not known how Modafinil works to keep you awake. It is thought to work by affecting certain substances in the brain that control the sleep/wake cycle.

Modafinil has effects on catecholamines and serotonin. It is also known as Provigil in the United States. These effects could be secondary to catecholamines and may have a selectivity for subcortical rather than cortical sites. Modafinil promotes wakefulness. The FDA has approved Modafinil to treat excessive sleepiness in narcolepsy, sleep disorders resulting from shift work and sleep disorder obstructive/hypopnea. In addition to its application for sleep disorders, it has been used off-label as a psychostimulant to treat cognitive dysfunction in some psychiatric conditions, such as schizophrenia, attention-deficit/hyperactivity disorder, and a general cognitive enhancer in normals.

Preclinical data suggest that Modafinil may improve working memory performance in a dose and delay-dependent fashion. Modafinil may also enhance the processing of context cues. Sustained dosing regimens can augment these effects. Studies in humans have shown Modafinil improves recognition memory, working memory, and other cognitive tasks in healthy subjects, whether or not they are sleeping deprivation. There is evidence Modafinil may improve attention and response inhibition among ADHD children and adolescents in psychiatric populations. Studies have also shown that Modafinil may improve cognitive functions in adult ADHD, major depression, and schizophrenia.

Modafinil seems to be associated with anxiety in humans and animals. However, the evidence is mixed and may be dose-dependent. Modafinil showed no similar effects to amphetamine in mice. The increased anxiety measures in mice due to increased latency in exploring a white compartment increased open field thigmotaxis and decreased time spent in open arms in an elevated plus-maze. Modafinil did not cause anxiety in monkeys after being administered at the increased nocturnal activity. This was confirmed by Hermant, Rambert and Duteil (1991). Wong et al. 1999 reported that Modafinil causes pressure to increase at doses between 200 and 800 mg. A second study on mood and cognitive function of healthy young adults revealed that modafinil 100 mg was associated with more anxiety symptoms than placebo. However, modafinil 200 mg did not cause these effects. Modafinil 400mg daily for three days was reported to make healthy adults feel calmer than those given a placebo. Similar results were found in placebo-controlled studies that modafinil administration was associated with anxiety in patients with the myotonic disorder, patients suffering from obstructive sleeping apnea, and multiple sclerosis. The literature indicates that Modafinil can cause stress in both healthy and clinical populations. Its role in augmenting the learning process of extinction (and its potential role as enhanced anxiety in this process) is still being studied.